Autism Symptoms Reversed in Mice

A team of researchers led by Nahum Sonenberg of McGill University in Montreal, Quebec, created a new model of mouse autism, and then reversed its symptoms. They began by genetically engineering mice so that they lacked the gene Eif4ebp2. The 4E-BP2 protein that this produces suppresses the translation of certain messenger RNAs, so knocking out Eif4ebp2 allows the proteins that these mRNAs produce to be synthesized at above normal levels.


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